Wear the prevention and protect your feet
  • A unique system for the prevention of the Diabetic Foot complication
  • Easy and comfortable as wearing a pair of socks
  • Deep, steady and continuous hydration of the foot skin
  • Based on transdermal hydrating technology, Harmowear™
  • More than 20 clinical studies available


What interest for people living with diabetes?

Chronic hyperglycemia may cause the development of serious complications such as neuropathy (dysfunctions of the nervous system), and arterial disease (reduced circulation in the arteries that carry blood to the lower limbs, obstructing the proper wound healing). People with neuropathy or arterial disease have a higher risk of development of ulcers and the Diabetic Foot complication. The Diabetic Foot is one of the most common complications of diabetes and consists of nervous and circulatory problems. The foot of a person with diabetes in a early stage of development of this complication shows already dryness and micro-lesions. Moving forward, it could develop deep ulcers with a high risk of infections, partial/total gangrenes, changes on the foot shape and on the way of walking. Moreover, the Diabetic Foot can also cause the amputation of some parts of the lower limbs or the entire of the foot.

What is it Difoprev®?

DIFOPREV® is a ready and easy to use system, designed specifically for the prevention of the Diabetic Foot complication. It consists of a starter kit including a pair of rechargeable socks and associated refill capsules for a monthly treatment. In addition, monthly refill capsules are also available. The socks release the active ingredient over 72 hors (3 days) and can be washed at any time during that period without any loss of efficacy. After 3 days, they need to be recharged by using a refill capsule, dissolve it in some water and soak the socks for 30 minutes . And so on.
The application should be repeated 2-6 times a year, according to functional skin conditions and following a professional advice.
DIFOPREV® unique nanotechnology is based on Meryl® high quality microfibre socks and specific refill capsules to replenish the socks with the active ingredients. This revolutionary technology consists of textiles loaded with a molecular film containing microencapsulated active components (a glycoprotein biotechnologically extracted from specific bacteria). The process guarantees a gradual release of these ingredients through the contact of the sock with the skin allowing a higher and deeper hydration during a longer period of time compared to any other topical solution.
Thanks to the increase of Elastin and Collagen type I and IV Difoprev® restores skin elasticity and integrity and repairs superficial micro-lesions (potential trigger for infections) while preserving a good physiological state of the skin.


Kit containing a pair of socks and 9 refill capsules for one month treatment
Package containing only 9 refill capsules for the repetition of one month treatment


Medical device class I


Meryl® socks
Active Ingredient: specific Glycoprotein that activates the production of Elastin and Class I and IV Collagen


Clinical tests in vivo were performed at hospitals and universities and have shown:
a extraordinary improvement of the keratosis
the restoration of the skin elasticity and of surface integrity
a significant improvement in the TEWL parameters
an improvement of the skin microcirculation
a tolerance without side effects


Prevention of “DIABETIC FOOT” preliminary results of a new delivery system with cosmetic microcapsules – Aluigi, G. Pirotta – IFSCC World Wide Wellness – Proceedings Cosmetics 2005 International conference – Firenze, 19-21 Settembre 2005
Valutazione del nuovo sistema DIFOPREV nella prevenzione e nel trattamento delle condizioni Pre-ulcerative nei pazienti con piede diabetico neuropatico: uno Studio prospettico randomizzato – E. Banchellini, L. Ambrosini et al. – Congresso Piede Diabetico 2005 – Firenze 5-7 Dicembre 2005
Applicazione delle nanotecnologie Alla gestione delle condizioni pre-ulcerative nel piede diabetico Neuropatico – E. Banchellini, L. Ambrosini, et al. – Poster session – 21° Congresso Nazionale SID – Milano, 17-20 Maggio 2006.
Trattamento di Prevenzione e Ripristino della cute nel piede diabetico con sistema Difoprev – R. Piro, F. De Bernardinis, et al. – Piede diabetico la realtà centro – Meridionale – 19-21 Ottobre 2006 – Paola (CS) 2006
Educazione e prevenzione piede diabetico – L. Aluigi – Giornate Nazionali di angiologia XXVIII Congresso Nazionale SIAPAV – Roma Novembre 2006
Nanotechnologies for the treatment of pre-ulcerative Condition of the diabetic foot – a prospective randomized trial – E. Banchellini, L. Ambrosini, et al. – V° International Symposium on the diabetic foot – 9-12 May 2007, Noordwijkerout – Netherands 2007
Facing the challenge of prevention in the diabetic Foot – A. Piaggesi – 13° National Congress of Internal Medicine 8-13 Ottobre 2007 – Athens – Greece 2007
Skin delivery of active ingredient from fabric – G. Pirotta – Publication “Cosmetic&Toiletries” Allured Publishing Corporation USA, Aprile 2008
Use of nanotechnology-Designed footsock in the management of preulcerative conditions in the Diabetic foot: results of a single, blind randomized study – E. Banchellini, S. Macchiarini, et al. – Publication The International Journal of Extremity Wounds – USA – Giugno 2008
Nanotechnologies for The management of pre-ulcerative conditions in the diabetic foot – E. Banchellini, S. Macchiarini, et al. – Poster session – Seven meeting of DFSG – 11-14 Settembre 2008 Il Ciocco Castelvecchio Pascoli Italy 2008
Therapeutic hosiery: An Essential Component Of Footwear for the Pathologic Foot – Douglas H. Richie jr., DPM – Publication Footwear & Podiatry- Podiatry Management – East Islip – NY USA – Ottobre 2008
What’s new in Orthopaedic Rehabilitation – H. Hosalcar, et al. – Publication The Journal of Bone And Joint Surgery – USA Ottobre 2008
Measurements in Diabetic Foot – A. Piaggesi, L. Rizzo, et al. – Publication Journal Of Wound Technology – Edition MF – Paris – France Gennaio 2009
Was gibt es neues in der Chirurgie? – Me_mer, Jähne, Neuhaus – Publication Germania 2009
Innovative approaches to Diabetic Foot care in Italy – A. Piaggesi – Publication Wounds International – UK – Febbraio 2010
Nanotechnologies in the treatment for the prevention and rehabilitation of the ischemic leg – E. Banchellini, L. Abruzzese, et al. – EviVenice 2010 – 22-23 Aprile 2010, Lido di Venezia – Italia 2010
Trattamento della Neuropatia autonomica nella prevenzione delle ulcere del piede diabetico – Pubblicazione Acta Vulnologica – Italia – Giugno 2010
Nanotechnologies for the prevention and treatment of preulcerative lesions of the ischemic foot – E. Banchellini, L. Abruzzese, et al. – VI° International Symposium on the diabetic foot – 11-14 May 2011, Noordwijkerhout, Netherlands 2011
Nanotechnology and Nanomedicine in Diabetes – A. Piaggesi, E. Iacopi, et al.- Edite by Lan-Anh Le, Ross J. Hunter and Victor R. Preedy – Science Publisher 2012 Pages 365-379 2012
L’impiego di nuove Biotecnologie nella cura e nella prevenzione del Piede Diabetico – D. Silvestri, V. Frison, et al. – Poster Session – XI Congresso Nazionale AIUC – Rimini 26-29 Settembre 2012
The Difoprev system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis – L. Aluigi – Publication – Journal of Vascular Diagnostics (Dove Press) – 16 Aprile 2014

Our Diabetes & Foot Porducts